Journal: Cureus
Article Title: Pharmacokinetics of Continuous Local Antibiotic Perfusion in Fresh-Frozen Cadaver Models of Hip and Knee Arthroplasties
doi: 10.7759/cureus.104181
Figure Lengend Snippet: Schematic diagrams illustrating the experimental setup for intramedullary antibiotic perfusion (iMAP) in the hip joint models. (a) In the total hip arthroplasty (THA) model, a single iMAP pin was inserted from the iliac crest toward the acetabular region to deliver gentamicin into the iliac bone marrow, from which antibiotics could enter the joint cavity through marrow-joint communication. Intra-articular drainage was achieved using a Salem Sump™ tube connected to negative-pressure wound therapy. (b) In the bipolar hemiarthroplasty (BHA) model, the same iMAP and drainage configuration was used, with additional trans-acetabular perforations created to facilitate antibiotic flow from the iliac bone marrow into the joint cavity, thereby enhancing intra-articular perfusion NPWT: negative-pressure wound therapy
Article Snippet: The intra-articular soft tissue access and drainage system comprised a 20-French Salem SumpTM double-lumen tube (Cardinal Health, Dublin, OH) inserted by entry into the joint; its wider lumen was connected to a negative-pressure wound therapy (NPWT) device (RENASYS TOUCH®, Smith & Nephew plc, London, United Kingdom) that applied continuous suction at -60 mmHg, while the narrower lumen was used for intra-articular infusion when specified.
Techniques: